Wednesday, April 1, 2026
Lead exposure in LAC children linked to cognitive deficits, behavioral changes, and adverse birth outcomes
Photo by Vitaly Gariev / Unsplash

Lead exposure in LAC children linked to cognitive deficits, behavioral changes, and adverse birth outcomes

Key Takeaway
Consider lead exposure as a risk factor for neurodevelopmental and adverse birth outcomes in LAC populations.

This systematic review synthesized evidence from 22 studies in Latin America and the Caribbean on lead exposure in children and pregnant women. Sources of exposure included glazed ceramics, mining, improper e-waste management, and contaminated water and soil. The review did not report a comparator group or primary outcome.

Key findings indicate some children had blood lead levels exceeding the international reference value of 3.5 μg·dL⁻¹. The evidence reported associations between lead exposure and cognitive deficits, learning difficulties, behavioral changes, and, in some contexts, juvenile delinquency. For reproductive health, associations with premature births and low birth weight were reported. The review did not provide specific effect sizes, absolute numbers, or statistical measures for these outcomes.

Safety and tolerability data were not reported. Major limitations include a lack of systematic biomonitoring and longitudinal studies in the region. The review's practice relevance lies in defining priorities for reproductive, child, and intergenerational health in LAC. The authors note these are reported associations, not established causation, and that no safe level of lead exposure is established.

View Original Abstract ↓
Lead exposure remains a persistent public health problem, with direct implications for reproductive and child health. Toxic and bioaccumulative, the metal persists in the environment due to historical use in fuels, paints, and ceramics, as well as industrial and mining activities. The aim of this study was to synthesize recent evidence on lead exposure in children from Latin America and the Caribbean (LAC), assessing outcomes related to human reproduction. A literature review was conducted according to PRISMA guidelines on the PubMed, Web of Science, and LILACS databases, covering the period from January 1, 2022, to January 30, 2026. The search was carried out on January 30, 2026, and only original articles in English, Portuguese, and Spanish were included. 165 studies were identified, of which 22 met the inclusion criteria. Four studies evaluated maternal exposure during pregnancy, while the remaining publications addressed exposures during childhood or in the general population. Some children participating in the included studies had blood lead levels exceeding the international reference value of 3.5 μg·dL−1. Glazed ceramics, mining activities, improper e-waste management, and water and soil contamination emerged as the main exposure sources. Negative effects included cognitive deficits, learning difficulties, behavioral changes, and, in some contexts, juvenile delinquency. Despite regulatory advances and updated reference values, shortcomings remain, such as a lack of systematic biomonitoring and longitudinal studies. Reproductive effects beyond childhood remain, such as premature births and low birth weight. With no safe level, defining priorities for reproductive, child, and intergenerational health in LAC is paramount.