Phase 2 Trial Evaluates mRNA Influenza Vaccines' Safety and Immunogenicity in Adults
This Phase 2 trial investigates the safety and immunogenicity of five mRNA-based influenza vaccines in 770 healthy adults. Primary outcomes include local and systemic reactions and adverse events post…
This study is testing new flu vaccines made with mRNA technology in healthy adults. Researchers want to see how safe these vaccines are and how well they help the body fight the flu.…
Dasatinib and Quercetin Show Promise in Improving Gait Speed in HIV-Associated Frailty
Phase II trial of dasatinib and quercetin (D+Q) in 82 HIV+ frail/prefrail adults shows potential in improving gait speed. Primary endpoint: occurrence of Grade 2+ AEs and premature discontinuations. R…
Researchers are studying a combination of two drugs to see if they can help older adults with HIV who are frail. The treatment aims to improve their physical function, like walking speed, over a 12-we…
Antibiotics for Appendicitis: 37.8% Recurrence, 44.3% Appendectomy at 10 Years
In a 10-year follow-up of the APPAC trial, 37.8% of patients treated with antibiotics for uncomplicated appendicitis experienced recurrence, and 44.3% underwent appendectomy. Complication rates were l…
This study looked at patients with uncomplicated appendicitis treated with antibiotics over ten years. It found that many patients had a return of appendicitis or needed surgery later, but antibiotics…
Rapid Diagnostics Align 65% of ICU Antibiotic Prescriptions with Pathogen Results
In the INHALE RCT, 65% of ICU antibiotic prescriptions aligned with BioFire FilmArray Pneumonia Panel results. Positive pathogen results led to 88% alignment, while negative results saw only 13% adher…
This study looked at how doctors use rapid tests to decide on antibiotics for lung infections in ICU patients. It found that while doctors often follow test results when they show an infection, they a…