Cardiology
COHORT
● Cohort
MAPSE Predicts Adverse Events in Acute Myocarditis; Lateral MAPSE Shows Superior Performance
Frontiers in Medicine
Published March 28, 2026
DOI ↗
This cohort study evaluated the prognostic value of mitral annular plane systolic excursion (MAPSE) in 46 patients with acute myocarditis compared to 26 healthy controls. All participants underwent cardiac magnetic resonance imaging to assess left atrial and ventricular strain and MAPSE using feature tracking. Patients were followed to identify those who experienced major adverse cardiovascular events (MACE), with 11 experiencing MACE and 35 not. Results showed significant reductions in left ventricular and atrial strain parameters and MAPSE in patients with MACE. ROC analysis indicated that MAPSE had a higher area under the curve (AUC) for identifying MACE. Kaplan-Meier analysis demonstrated a significant increase in mortality risk with decreasing lateral and septal MAPSE (log-rank P = 0.0025, P = 0.0065). Adjusted Cox regression analysis revealed that age (HR 1.139, 95% CI 1.056–1.228), lateral MAPSE (HR 0.594, 95% CI 0.355–0.955), and septal MAPSE (HR 0.647, 95% CI 0.420–0.995) were significantly associated with MACE. The predictive model including both lateral and septal MAPSE did not outperform lateral MAPSE alone (AUC = 0.8831 vs. AUC = 0.9095). The study concludes that MAPSE, particularly lateral MAPSE, is a valuable prognostic tool for adverse cardiovascular events in acute myocarditis.
AI Accuracy Review: 9/10
· Auto-published
If you or someone you care about has acute myocarditis, understanding heart function is crucial. A measurement known as mitral annular plane systolic excursion (MAPSE) can provide important insights. In a study involving patients with acute myocarditis, those who experienced serious cardiovascular events had significantly lower MAPSE levels compared to those who did not. This means that monitoring MAPSE could help doctors identify patients at greater risk of complications, including death. The study found that both lateral and septal MAPSE were strongly linked to these risks, with lower values indicating a higher chance of adverse outcomes. This information could be vital for healthcare providers in deciding how to manage and treat patients with acute myocarditis, ensuring that those at higher risk receive the attention they need.
What this means for you: MAPSE is a valuable tool for predicting serious risks in patients with acute myocarditis.
View Original Abstract ↓
PurposeMitral annular plane systolic excursion (MAPSE) has prognostic value as a surrogate indicator of ventricular function in cardiovascular disease, but its prognostic value in patients with acute myocarditis is unclear.MethodsOur cohort included 46 patients with acute myocarditis and 26 healthy controls, all of whom underwent cardiac magnetic resonance. Left atrial and left ventricular strain and MAPSE were assessed using feature tracking, and patients were followed up in a group that experienced a major adverse cardiovascular event (MACE) (n = 11) and a group that did not experience a MACE (n = 35). Cox regression modelling was used to assess the prognostic value of MAPSE in acute myocarditis.ResultsLeft ventricular strain parameters (including global longitudinal, circumferential, and radial strain), left atrial strain parameters (reservoir and conduit strain), and MAPSE were significantly reduced compared with patients without MACE. Receiver operating characteristic (ROC) curve showed that MAPSE had a higher area under the curve (AUC) in identifying MACE. By Kaplan–Meier analysis, the risk of death increased significantly with decreasing lateral and septal MAPSE (log-rank P = 0.0025, P = 0.0065). After adjusting for clinical and imaging risk factors, age (HR 1.139, 95%CI 1.056–1.228), lateral MAPSE (HR 0.594, 95%CI 0.355–0.955), and septal MAPSE (HR 0.647, 95%CI 0.420–0.995) were significantly associated with MACE. The ROC curves showed that the model including both lateral and septal MAPSE did not improve predictive performance compared to lateral MAPSE alone (AUC = 0.8831 vs. AUC = 0.9095).ConclusionMAPSE has prognostic value for adverse cardiovascular events in patients with acute myocarditis, and lateral MAPSE has better predictive performance.
