Perspective highlights diagnostic overlap between idiopathic multicentric Castleman disease and systemic lupus erythematosus Castleman disease can resemble lupus, requiring careful diagnosis for proper treatment

A perspective article discusses the clinical resemblance between idiopathic multicentric Castleman disease (iMCD) and systemic lupus erythematosus (SLE). Overlapping features include fever, lymphadenopathy, cytopenias, renal involvement, and elevated inflammatory markers. Clinicians should consider iMCD in patients with atypical or refractory lupus-like presentations.

A medical perspective article explains how idiopathic multicentric Castleman disease (iMCD) can look very similar to systemic lupus erythematosus (SLE). Both conditions share features like fever, swollen lymph nodes, and abnormal blood tests. This similarity means doctors need to be careful to tell them apart, as they require different treatments.