Diabetes & Endocrinology
META ANALYSIS
● Meta-analysis
High Infection Rates in Type 2 Diabetes: Periodontitis Prevalence at 33.6%
Journal of global health
Published March 27, 2026
Fu Xue-Lei, Chen Wen-Jun, Zhao Hui-Mei, Li Meng-Di, Zhuang Meng-Yi, Xiao Yang, Wu Bei, Guo Jia
PubMed ↗
DOI ↗
This systematic review and meta-analysis evaluated the prevalence and incidence of infections among individuals with type 2 diabetes by analyzing data from 70 studies. The study aimed to provide a clearer understanding of infection risks in this population to inform clinical decision-making. The primary findings indicated that severe periodontitis had the highest pooled prevalence at 33.6% (95% CI: 23.7-44.2), followed by skin infections at 28.6% (95% CI: 20.7-37.2) and urinary tract infections at 9.7% (95% CI: 6.5-13.5). In terms of incidence, lower respiratory tract infections were most common, with an incidence of 1409.2 per 10,000 person-years (95% CI: 1048.1-1894.6), followed by skin infections at 664.1 (95% CI: 39.4-11203.9), upper respiratory tract infections at 553.6 (95% CI: 12.7-24149.2), and urinary tract infections at 500.6 (95% CI: 171.3-1462.6). No specific safety or adverse events were reported in this meta-analysis. These findings highlight the need for heightened surveillance and targeted infection prevention strategies in patients with type 2 diabetes, particularly focusing on dental health and respiratory infections.
AI Accuracy Review: 10/10
· Auto-published
This study focuses on type 2 diabetes, a condition where the body has trouble using insulin, leading to high blood sugar levels. Researchers reviewed many studies to find out how often infections occur in people with this condition. They discovered that severe gum disease is very common among these patients, and lung infections happen frequently as well. This information is important because it can help doctors and patients understand which infections to watch for and how to manage them better. However, it's essential to remember that while these findings highlight common infections, individual experiences may vary. Patients should continue to work closely with their healthcare providers to monitor their health and address any concerns about infections.
What this means for you: People with type 2 diabetes should be aware of their higher risk for infections, especially gum and lung infections.
View Original Abstract ↓
BACKGROUND: Although evidence suggests a greater susceptibility of type 2 diabetes to infections, the prevalence and incidence of different types of infections vary greatly, affecting clinical decision-making. We aimed to estimate the aggregate prevalence and incidence of infections among people with type 2 diabetes.
METHODS: We searched PubMed, Embase, Web of Science, and Cochrane Library from inception to August 2025. We combined the terms type 2 diabetes, infection, and prevalence/incidence for the search. We included studies with data on infection prevalence (percentage) and/or incidence (number of person-years at risk) among patients with type 2 diabetes. We used the quality-effects model to estimate effects and 95% confidence intervals (CIs).
RESULTS: We included 70 studies in this meta-analysis. Severe periodontitis had the highest pooled prevalence among people with type 2 diabetes (33.6%; 95% CI = 23.7-44.2), followed by skin infections (28.6%; 95% CI = 20.7-37.2) and urinary tract infections (9.7%; 95% CI = 6.5-13.5). Lower respiratory tract infections had the highest pooled incidence per 10 000 person-years (1409.2; 95% CI = 1048.1-1894.6), followed by skin infections (664.1; 95% CI = 39.4-11203.9), upper respiratory tract infections (553.6; 95% CI = 12.7-24149.2) and urinary tract infections (500.6; 95% CI = 171.3-1462.6).
CONCLUSIONS: Among people with type 2 diabetes, the prevalence of severe periodontitis and the incidence of lower respiratory tract infections were the highest. We pinpointed recently prevalent high-occurrence infections in type 2 diabetes, helping to update surveillance and control priorities for diabetes care.
REGISTRATION: PROSPERO: CRD42024489267.